Cleo & Cuquin is a Spanish animated television series for children. It tells the adventure story of Cleo, a six-year-old girl, and her younger brother Cuquin, who is always in trouble. They embark on fun and imaginative adventures with their siblings Tete, Pelusin, Colitas and Maripi.

The show is known for its bright and colorful animations, great music, and characters that are easily identified by children. It became popular in many Spanish-speaking countries and was translated into many languages.